Discovery and selection of TMC114, a next generation HIV-1 protease inhibitor. [electronic resource]
Producer: 20050503Description: 1813-22 p. digitalISSN:- 0022-2623
- Administration, Oral
- Animals
- Biological Availability
- Cell Line
- Crystallography, X-Ray
- Darunavir
- Dogs
- Drug Resistance, Multiple, Viral
- HIV Protease -- genetics
- HIV Protease Inhibitors -- chemical synthesis
- HIV-1 -- drug effects
- Humans
- In Vitro Techniques
- Microsomes, Liver -- metabolism
- Models, Molecular
- Molecular Conformation
- Mutation
- Rats
- Stereoisomerism
- Structure-Activity Relationship
- Sulfonamides -- chemical synthesis
- Thermodynamics
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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