Dimerization of MLL fusion proteins and FLT3 activation synergize to induce multiple-lineage leukemogenesis. [electronic resource]
Producer: 20050628Description: 919-29 p. digitalISSN:- 0021-9738
- Animals
- Cell Transformation, Neoplastic
- Cell Transplantation
- Cells, Cultured
- Cytoskeletal Proteins
- DNA Damage
- DNA-Binding Proteins -- chemistry
- Dimerization
- Enzyme Activation
- GTP-Binding Proteins -- chemistry
- Hematopoietic Stem Cells -- cytology
- Histone-Lysine N-Methyltransferase
- Humans
- Infant
- Leukemia, Myeloid, Acute -- metabolism
- Liver -- pathology
- Mice
- Mice, Inbred C57BL
- Myeloid-Lymphoid Leukemia Protein
- Oncogene Proteins, Fusion -- chemistry
- Protein Structure, Tertiary
- Proto-Oncogene Proteins -- metabolism
- Proto-Oncogenes -- genetics
- Receptor Protein-Tyrosine Kinases -- metabolism
- Recombinant Fusion Proteins -- chemistry
- Septins
- Spleen -- pathology
- Transcription Factors -- chemistry
- fms-Like Tyrosine Kinase 3
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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