Suppression of Pdx-1 perturbs proinsulin processing, insulin secretion and GLP-1 signalling in INS-1 cells. [electronic resource]
Producer: 20050906Description: 720-31 p. digitalISSN:- 0012-186X
- Adenosine Triphosphate -- metabolism
- Animals
- Calcium Signaling -- physiology
- Cell Line, Tumor
- Cyclic AMP -- metabolism
- Dose-Response Relationship, Drug
- Doxycycline -- pharmacology
- Exocytosis -- physiology
- Gene Expression -- drug effects
- Gene Expression Regulation, Neoplastic -- drug effects
- Glucagon-Like Peptide-1 Receptor
- Glucokinase -- genetics
- Glucose -- metabolism
- Glycolysis
- Homeodomain Proteins -- genetics
- Human Growth Hormone -- genetics
- Insulin -- metabolism
- Insulin Secretion
- Islets of Langerhans -- drug effects
- Mitochondria -- metabolism
- Mutation
- Proinsulin -- metabolism
- Proprotein Convertases -- genetics
- RNA, Messenger -- genetics
- Rats
- Receptor Protein-Tyrosine Kinases -- genetics
- Receptor, Fibroblast Growth Factor, Type 1
- Receptors, Fibroblast Growth Factor -- genetics
- Receptors, Glucagon -- genetics
- Signal Transduction -- physiology
- Time Factors
- Trans-Activators -- genetics
- Transfection
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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