The benzo[c]phenanthridine alkaloid, sanguinarine, is a selective, cell-active inhibitor of mitogen-activated protein kinase phosphatase-1. [electronic resource]
Producer: 20050712Description: 19078-86 p. digitalISSN:- 0021-9258
- Alkaloids -- chemistry
- Benzophenanthridines
- Catalytic Domain
- Cell Cycle Proteins -- antagonists & inhibitors
- Cell Line, Tumor
- DNA Damage
- Dose-Response Relationship, Drug
- Dual Specificity Phosphatase 1
- Dual Specificity Phosphatase 6
- Electrophoresis, Gel, Two-Dimensional
- Enzyme Inhibitors -- pharmacology
- Extracellular Signal-Regulated MAP Kinases -- metabolism
- Gene Library
- HeLa Cells
- Humans
- Immediate-Early Proteins -- antagonists & inhibitors
- Inhibitory Concentration 50
- Isoquinolines
- JNK Mitogen-Activated Protein Kinases -- metabolism
- MAP Kinase Kinase 4
- Microscopy, Fluorescence
- Mitogen-Activated Protein Kinase Kinases -- metabolism
- Models, Chemical
- Models, Statistical
- Neoplasms -- drug therapy
- Phosphoprotein Phosphatases -- antagonists & inhibitors
- Phosphorylation
- Plant Extracts -- pharmacology
- Protein Phosphatase 1
- Protein Tyrosine Phosphatase, Non-Receptor Type 1
- Protein Tyrosine Phosphatases -- antagonists & inhibitors
- Time Factors
- Transfection
- cdc25 Phosphatases -- metabolism
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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