Aerosol-, but not intradermal-immunization with the live vaccine strain of Francisella tularensis protects mice against subsequent aerosol challenge with a highly virulent type A strain of the pathogen by an alphabeta T cell- and interferon gamma- dependent mechanism. [electronic resource]
Producer: 20051103Description: 2477-85 p. digitalISSN:- 0264-410X
- Administration, Inhalation
- Animals
- Bacterial Vaccines -- administration & dosage
- CD4-Positive T-Lymphocytes -- immunology
- CD8-Positive T-Lymphocytes -- immunology
- Cytokines -- analysis
- Disease Models, Animal
- Female
- Francisella tularensis -- immunology
- Injections, Intradermal
- Interferon-gamma -- immunology
- Lung -- immunology
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C3H
- Tularemia -- prevention & control
- Vaccines, Attenuated -- administration & dosage
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
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