Dehydroepiandrosterone inhibits the proliferation of human umbilical vein endothelial cells by enhancing the expression of p53 and p21, restricting the phosphorylation of retinoblastoma protein, and is androgen- and estrogen-receptor independent. [electronic resource]
Producer: 20050418Description: 1343-53 p. digitalISSN:- 1742-464X
- Cell Cycle Proteins -- drug effects
- Cell Division -- drug effects
- Cyclin-Dependent Kinase Inhibitor p21
- DNA -- biosynthesis
- Dehydroepiandrosterone -- pharmacology
- Endothelium, Vascular -- cytology
- Enzyme Inhibitors
- Gene Expression Regulation -- drug effects
- Humans
- Phosphorylation
- RNA, Messenger -- genetics
- Receptors, Androgen -- physiology
- Receptors, Estrogen -- physiology
- Retinoblastoma Protein -- drug effects
- Reverse Transcriptase Polymerase Chain Reaction
- Thymidine -- metabolism
- Tumor Suppressor Protein p53 -- drug effects
- Umbilical Veins
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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