Combined pharmacological, mutational and cell biology approaches indicate that p53-dependent caspase 3 activation triggered by cellular prion is dependent on its endocytosis. [electronic resource]
Producer: 20050422Description: 1399-407 p. digitalISSN:- 0022-3042
- Animals
- Apoptosis -- physiology
- Caspase 3
- Caspases -- metabolism
- Cell Compartmentation -- physiology
- Cell Line
- Endocytosis -- physiology
- Enzyme Activation -- physiology
- Enzyme Inhibitors -- pharmacology
- Humans
- Mice
- Mutation -- genetics
- Peptide Hydrolases -- metabolism
- PrPC Proteins -- genetics
- Prion Diseases -- metabolism
- Proteasome Endopeptidase Complex -- metabolism
- Proteasome Inhibitors
- Protein Transport -- physiology
- Sucrose -- pharmacology
- Transcriptional Activation -- physiology
- Transferrin -- metabolism
- Tumor Suppressor Protein p53 -- metabolism
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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