The insulin-like growth factor-I receptor kinase inhibitor, NVP-ADW742, sensitizes small cell lung cancer cell lines to the effects of chemotherapy. [electronic resource]
Producer: 20050728Description: 1563-71 p. digitalISSN:- 1078-0432
- Antineoplastic Agents -- pharmacology
- Apoptosis -- drug effects
- Carboplatin -- pharmacology
- Carcinoma, Small Cell -- drug therapy
- Cell Division -- drug effects
- Cell Line, Tumor
- Cell Survival -- drug effects
- Dose-Response Relationship, Drug
- Drug Synergism
- Enzyme-Linked Immunosorbent Assay
- Etoposide -- pharmacology
- Gene Expression Regulation, Neoplastic -- drug effects
- Humans
- In Situ Nick-End Labeling
- Insulin-Like Growth Factor I -- pharmacology
- Lung Neoplasms -- drug therapy
- Protein Kinase Inhibitors -- pharmacology
- Protein Serine-Threonine Kinases -- metabolism
- Proto-Oncogene Proteins -- metabolism
- Proto-Oncogene Proteins c-akt
- Pyrimidines -- pharmacology
- Pyrroles -- pharmacology
- RNA, Messenger -- genetics
- Receptor, IGF Type 1 -- antagonists & inhibitors
- Vascular Endothelial Growth Factor A -- genetics
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Publication Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
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