Spinal distribution and metabolism of 2'-O-(2-methoxyethyl)-modified oligonucleotides after intrathecal administration in rats. [electronic resource]
Producer: 20050606Description: 705-15 p. digitalISSN:- 0306-4522
- Animals
- Dose-Response Relationship, Drug
- Drug Administration Schedule
- Ganglia, Spinal -- anatomy & histology
- Glial Fibrillary Acidic Protein -- metabolism
- Immunohistochemistry -- methods
- Injections, Spinal -- methods
- Male
- Oligonucleotides, Antisense -- administration & dosage
- Phosphopyruvate Hydratase -- metabolism
- Protein Kinase C -- genetics
- Protein Kinase C-alpha
- RNA, Messenger -- biosynthesis
- Rats
- Rats, Sprague-Dawley
- Reverse Transcriptase Polymerase Chain Reaction -- methods
- Spinal Cord -- anatomy & histology
- Thionucleotides -- administration & dosage
- Time Factors
- Tissue Distribution
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Publication Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
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