Investigation of the role of Bax, p21/Waf1 and p53 as determinants of cellular responses in HCT116 colorectal cancer cells exposed to the novel cytotoxic ruthenium(II) organometallic agent, RM175. [electronic resource]
Producer: 20050621Description: 577-83 p. digitalISSN:- 0344-5704
- Antineoplastic Agents -- pharmacology
- Apoptosis -- drug effects
- Cell Cycle -- drug effects
- Cell Cycle Proteins -- genetics
- Cell Survival -- drug effects
- Cloning, Molecular
- Colorectal Neoplasms -- metabolism
- Cyclin-Dependent Kinase Inhibitor p21
- Dose-Response Relationship, Drug
- Drug Screening Assays, Antitumor
- HCT116 Cells
- Humans
- Immunoblotting
- Inhibitory Concentration 50
- Organometallic Compounds -- pharmacology
- Proto-Oncogene Proteins c-bcl-2 -- genetics
- Ruthenium -- pharmacology
- Tumor Suppressor Protein p53 -- genetics
- bcl-2-Associated X Protein
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Publication Type: Journal Article
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