Silymarin induces apoptosis primarily through a p53-dependent pathway involving Bcl-2/Bax, cytochrome c release, and caspase activation. [electronic resource]
Producer: 20050728Description: 207-16 p. digitalISSN:- 1535-7163
- Amino Acid Chloromethyl Ketones -- pharmacology
- Animals
- Apoptosis
- Apoptotic Protease-Activating Factor 1
- Caspase 3
- Caspase Inhibitors
- Caspases -- metabolism
- Cell Line
- Cysteine Proteinase Inhibitors -- pharmacology
- Cytochromes c -- metabolism
- Down-Regulation
- Fibroblasts -- drug effects
- Keratinocytes -- drug effects
- Mice
- Phosphorylation -- drug effects
- Poly(ADP-ribose) Polymerases -- metabolism
- Proteins -- metabolism
- Proto-Oncogene Proteins c-bcl-2 -- metabolism
- Silybin
- Silymarin -- pharmacology
- Tumor Suppressor Protein p53 -- genetics
- bcl-2-Associated X Protein
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
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