The microtubule stabilizing agent discodermolide is a potent inducer of accelerated cell senescence. [electronic resource]
Producer: 20060505Description: 501-7 p. digitalISSN:- 1551-4005
- Alkanes -- pharmacology
- Antineoplastic Agents -- pharmacology
- Antineoplastic Agents, Phytogenic -- pharmacology
- Bromodeoxyuridine -- pharmacology
- Carbamates -- pharmacology
- Cell Line, Tumor
- Cellular Senescence
- Flow Cytometry
- Gene Expression Regulation
- Humans
- Hydrogen-Ion Concentration
- Inhibitory Concentration 50
- Lactones -- pharmacology
- Microtubules -- chemistry
- Mitogen-Activated Protein Kinase 1 -- metabolism
- Mitogen-Activated Protein Kinase 3 -- metabolism
- Mitosis
- Paclitaxel -- pharmacology
- Phenotype
- Pyrones -- pharmacology
- Signal Transduction
- Time Factors
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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