Synergistic interactions between imatinib mesylate and the novel phosphoinositide-dependent kinase-1 inhibitor OSU-03012 in overcoming imatinib mesylate resistance. [electronic resource]
Producer: 20050607Description: 4021-7 p. digitalISSN:- 0006-4971
- 3-Phosphoinositide-Dependent Protein Kinases
- Animals
- Antineoplastic Agents -- pharmacology
- Apoptosis -- drug effects
- Benzamides
- Cell Line, Tumor
- Drug Resistance, Neoplasm -- drug effects
- Drug Synergism
- Enzyme Activation -- drug effects
- Fusion Proteins, bcr-abl -- genetics
- Imatinib Mesylate
- Mice
- Mutation -- genetics
- Phosphorylation
- Piperazines -- pharmacology
- Protein Kinase Inhibitors -- pharmacology
- Protein Serine-Threonine Kinases -- antagonists & inhibitors
- Proto-Oncogene Proteins -- antagonists & inhibitors
- Proto-Oncogene Proteins c-akt
- Pyrazoles -- pharmacology
- Pyrimidines -- pharmacology
- Signal Transduction -- drug effects
- Sulfonamides -- pharmacology
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
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