Human colon cancer cells lacking Bax resist curcumin-induced apoptosis and Bax requirement is dispensable with ectopic expression of Smac or downregulation of Bcl-XL. [electronic resource]
Producer: 20050503Description: 713-23 p. digitalISSN:- 0143-3334
- Antineoplastic Agents -- pharmacology
- Apoptosis -- drug effects
- Apoptosis Inducing Factor
- Caspase Inhibitors
- Caspases -- metabolism
- Colonic Neoplasms -- metabolism
- Complement Membrane Attack Complex
- Complement System Proteins
- Curcumin -- pharmacology
- Cytochromes c -- metabolism
- Down-Regulation
- Drug Resistance, Neoplasm
- Enzyme Activation -- drug effects
- Flavoproteins -- antagonists & inhibitors
- Glycoproteins -- antagonists & inhibitors
- Humans
- Membrane Proteins -- antagonists & inhibitors
- Oligonucleotides, Antisense -- pharmacology
- Proto-Oncogene Proteins c-bcl-2 -- genetics
- Tumor Cells, Cultured
- bcl-2-Associated X Protein
- bcl-X Protein
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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