A tetracycline-regulated adenovirus encoding dominant-negative caspase-9 is regulated in rat brain and protects against neurotoxin-induced cell death in vitro, but not in vivo. [electronic resource]
Producer: 20050329Description: S80-94 p. digitalISSN:- 0014-4886
- Adenoviridae -- drug effects
- Animals
- Apoptosis
- Brain -- drug effects
- Caspase 9
- Caspases -- genetics
- Cell Line
- Gene Expression Regulation -- drug effects
- Gene Transfer Techniques
- Genes, Dominant
- Genes, Reporter
- Genetic Vectors -- drug effects
- Green Fluorescent Proteins -- genetics
- HeLa Cells
- Humans
- Kidney -- cytology
- Male
- Neostriatum -- drug effects
- Neuroprotective Agents -- pharmacology
- Neurotoxins
- Oxidopamine
- Parkinsonian Disorders -- metabolism
- Rats
- Rats, Inbred F344
- Tetracycline -- pharmacology
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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