Tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis is inhibited by Bcl-2 but restored by the small molecule Bcl-2 inhibitor, HA 14-1, in human colon cancer cells. [electronic resource]
Producer: 20050930Description: 8284-92 p. digitalISSN:- 1078-0432
- Annexin A5 -- metabolism
- Antineoplastic Agents -- pharmacology
- Apoptosis -- drug effects
- Apoptosis Regulatory Proteins
- BH3 Interacting Domain Death Agonist Protein
- Benzopyrans -- pharmacology
- Carrier Proteins -- metabolism
- Caspase 9
- Caspase Inhibitors
- Colonic Neoplasms -- metabolism
- Cytochromes c -- metabolism
- Enzyme Activation -- drug effects
- Enzyme Inhibitors -- pharmacology
- Humans
- Intracellular Signaling Peptides and Proteins
- Membrane Glycoproteins -- pharmacology
- Membrane Proteins -- metabolism
- Mitochondrial Proteins -- metabolism
- Nitriles -- pharmacology
- Oligopeptides -- pharmacology
- Proteins -- metabolism
- Proto-Oncogene Proteins c-bcl-2 -- antagonists & inhibitors
- Recombinant Proteins -- pharmacology
- TNF-Related Apoptosis-Inducing Ligand
- Tumor Cells, Cultured
- Tumor Necrosis Factor-alpha -- pharmacology
- Tumor Stem Cell Assay
- X-Linked Inhibitor of Apoptosis Protein
- bcl-2 Homologous Antagonist-Killer Protein
- bcl-2-Associated X Protein
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
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