Hyperforin, the active component of St. John's wort, induces IL-8 expression in human intestinal epithelial cells via a MAPK-dependent, NF-kappaB-independent pathway. [electronic resource]
Producer: 20050630Description: 623-36 p. digitalISSN:- 0271-9142
- Antidepressive Agents -- pharmacology
- Bridged Bicyclo Compounds -- pharmacology
- Cell Line
- Gene Expression Regulation -- drug effects
- Humans
- Hypericum -- chemistry
- Inflammation Mediators
- Interleukin-8 -- genetics
- Intestinal Mucosa -- cytology
- Mitogen-Activated Protein Kinases
- NF-kappa B -- metabolism
- Phloroglucinol -- analogs & derivatives
- Phytotherapy -- adverse effects
- Signal Transduction
- Terpenes -- pharmacology
- Transcription Factor AP-1 -- metabolism
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
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