Critical role of CDK2 for melanoma growth linked to its melanocyte-specific transcriptional regulation by MITF. [electronic resource]
Producer: 20050315Description: 565-76 p. digitalISSN:- 1535-6108
- Blotting, Western
- CDC2-CDC28 Kinases -- genetics
- Cell Line, Tumor
- Cell Proliferation
- Cell Survival -- drug effects
- Chromatin Immunoprecipitation
- Cyclin-Dependent Kinase 2
- Cyclin-Dependent Kinases -- genetics
- DNA-Binding Proteins -- genetics
- E-Box Elements -- physiology
- Fibroblasts -- metabolism
- Flow Cytometry
- Gene Expression
- Gene Expression Regulation, Neoplastic
- Genes, Reporter -- genetics
- Humans
- Melanocytes -- metabolism
- Melanoma -- metabolism
- Membrane Glycoproteins
- Microphthalmia-Associated Transcription Factor
- Mutation
- Oligonucleotide Array Sequence Analysis
- Protein Kinase Inhibitors -- pharmacology
- Proteins -- genetics
- Proto-Oncogene Proteins c-bcl-2 -- metabolism
- Purines -- pharmacology
- RNA, Small Interfering -- genetics
- Reverse Transcriptase Polymerase Chain Reaction
- Roscovitine
- S Phase -- physiology
- Transcription Factors -- genetics
- Transcription, Genetic
- Transfection
- bcl-X Protein
- gp100 Melanoma Antigen
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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