Potent inhibition of huntingtin aggregation and cytotoxicity by a disulfide bond-free single-domain intracellular antibody. [electronic resource]
Producer: 20050204Description: 17616-21 p. digitalISSN:- 0027-8424
- Animals
- Antibodies -- chemistry
- Antibody Affinity
- Cell Line
- Directed Molecular Evolution
- Disulfides
- Humans
- Huntingtin Protein
- Huntington Disease -- metabolism
- Models, Molecular
- Mutation -- genetics
- Nerve Tissue Proteins -- chemistry
- Nuclear Proteins -- chemistry
- Protein Binding -- drug effects
- Protein Denaturation -- drug effects
- Protein Engineering
- Protein Structure, Quaternary -- drug effects
- Saccharomyces cerevisiae
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
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