Vector targeting makes 5-fluorouracil chemotherapy less toxic and more effective in animal models of epithelial neoplasms. [electronic resource]
Producer: 20050517Description: 7738-46 p. digitalISSN:- 1078-0432
- Adenoviridae -- genetics
- Animals
- Antimetabolites, Antineoplastic -- therapeutic use
- Camptothecin -- analogs & derivatives
- Carboxylesterase -- metabolism
- Cell Line, Tumor
- Combined Modality Therapy
- Cytosine Deaminase -- genetics
- Disease Models, Animal
- Drug Delivery Systems
- Female
- Fluorouracil -- therapeutic use
- Genetic Therapy -- methods
- Genetic Vectors
- Humans
- Inhibitory Concentration 50
- Irinotecan
- Mice
- Mice, Nude
- Microscopy, Fluorescence
- Neoplasms, Glandular and Epithelial -- drug therapy
- Promoter Regions, Genetic
- RNA, Messenger -- metabolism
- Ribosomes -- metabolism
- Thymidylate Synthase -- metabolism
- Time Factors
- Transcription, Genetic
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
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