The liver X receptor ligand T0901317 decreases amyloid beta production in vitro and in a mouse model of Alzheimer's disease. [electronic resource]
Producer: 20050405Description: 4079-88 p. digitalISSN:- 0021-9258
- Alzheimer Disease -- metabolism
- Amyloid beta-Protein Precursor -- genetics
- Animals
- Anticholesteremic Agents -- pharmacology
- Apolipoprotein A-I -- chemistry
- Blotting, Western
- Brain -- metabolism
- Cloning, Molecular
- DNA, Complementary -- metabolism
- DNA-Binding Proteins
- Disease Models, Animal
- Enzyme-Linked Immunosorbent Assay
- Fibroblasts -- metabolism
- Humans
- Hydrocarbons, Fluorinated
- Immunoprecipitation
- Ligands
- Liver X Receptors
- Mice
- Mice, Inbred C57BL
- Mice, Transgenic
- Neurons -- metabolism
- Orphan Nuclear Receptors
- Protein Binding
- Receptors, Cytoplasmic and Nuclear -- metabolism
- Simplexvirus -- metabolism
- Sulfonamides
- Time Factors
- Transcription, Genetic
- Transfection
- Up-Regulation
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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