Binding to nonmethylated CpG DNA is essential for target recognition, transactivation, and myeloid transformation by an MLL oncoprotein. [electronic resource]
Producer: 20050104Description: 10470-8 p. digitalISSN:- 0270-7306
- Amino Acid Motifs
- Amino Acid Sequence
- Animals
- Blotting, Western
- Bone Marrow Cells -- cytology
- COS Cells
- Cell Line
- Cell Nucleus -- metabolism
- Cell Transformation, Neoplastic
- CpG Islands
- Cytoplasm -- metabolism
- DNA -- chemistry
- DNA Methylation
- DNA-Binding Proteins -- genetics
- Gene Deletion
- Genes, Reporter
- Histone-Lysine N-Methyltransferase
- Humans
- Luciferases -- metabolism
- Mice
- Microscopy, Fluorescence
- Models, Genetic
- Molecular Sequence Data
- Mutation
- Myeloid-Lymphoid Leukemia Protein
- Plasmids -- metabolism
- Point Mutation
- Protein Binding
- Protein Structure, Tertiary
- Proto-Oncogenes -- genetics
- Sequence Homology, Amino Acid
- Transcription Factors -- genetics
- Transcriptional Activation
- Translocation, Genetic
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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