Discovery of positive allosteric modulators for the metabotropic glutamate receptor subtype 5 from a series of N-(1,3-diphenyl-1H- pyrazol-5-yl)benzamides that potentiate receptor function in vivo. [electronic resource]
Producer: 20050103Description: 5825-8 p. digitalISSN:- 0022-2623
- Allosteric Regulation
- Animals
- Antipsychotic Agents -- chemical synthesis
- Benzamides -- chemical synthesis
- Brain -- metabolism
- CHO Cells
- Cricetinae
- Cricetulus
- Glutamic Acid -- pharmacology
- Humans
- In Vitro Techniques
- Pyrazoles -- chemical synthesis
- Rats
- Receptor, Metabotropic Glutamate 5
- Receptors, Metabotropic Glutamate -- drug effects
- Reflex, Startle -- drug effects
- Structure-Activity Relationship
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Publication Type: Journal Article
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