Alterations in mitogen-activated protein kinase kinase and extracellular regulated kinase signaling in theca cells contribute to excessive androgen production in polycystic ovary syndrome. [electronic resource]
Producer: 20050607Description: 379-90 p. digitalISSN:- 0888-8809
- Adenoviridae -- metabolism
- Androgens -- biosynthesis
- Animals
- Blotting, Western
- Cell Line
- Cells, Cultured
- Dehydroepiandrosterone -- metabolism
- Dose-Response Relationship, Drug
- Enzyme Inhibitors -- pharmacology
- Extracellular Signal-Regulated MAP Kinases -- metabolism
- Female
- Flavonoids -- pharmacology
- Genes, Dominant
- Humans
- Insulin -- metabolism
- Lac Operon
- Mitogen-Activated Protein Kinase Kinases -- metabolism
- Mutation
- Ovary -- metabolism
- Phosphorylation
- Polycystic Ovary Syndrome -- metabolism
- Promoter Regions, Genetic
- RNA, Messenger -- metabolism
- Steroid 17-alpha-Hydroxylase -- biosynthesis
- Steroids -- metabolism
- Theca Cells -- metabolism
- Time Factors
- Transfection
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
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