Farnesyltransferase inhibitors interact synergistically with the Chk1 inhibitor UCN-01 to induce apoptosis in human leukemia cells through interruption of both Akt and MEK/ERK pathways and activation of SEK1/JNK. [electronic resource]
Producer: 20050303Description: 1706-16 p. digitalISSN:- 0006-4971
- Acute Disease
- Alkyl and Aryl Transferases -- antagonists & inhibitors
- Antineoplastic Combined Chemotherapy Protocols
- Apoptosis -- drug effects
- Caspases -- metabolism
- Cell Transformation, Neoplastic -- drug effects
- Checkpoint Kinase 1
- Dose-Response Relationship, Drug
- Drug Synergism
- Enzyme Activation -- drug effects
- Enzyme Inhibitors -- metabolism
- Extracellular Signal-Regulated MAP Kinases -- antagonists & inhibitors
- Farnesyltranstransferase
- HL-60 Cells
- Humans
- JNK Mitogen-Activated Protein Kinases -- metabolism
- Jurkat Cells
- Leukemia, Myeloid -- drug therapy
- MAP Kinase Kinase 4 -- metabolism
- MAP Kinase Signaling System -- drug effects
- Membrane Potentials -- drug effects
- Methionine -- analogs & derivatives
- Mitochondria -- drug effects
- Protein Kinase Inhibitors -- metabolism
- Protein Kinases -- metabolism
- Protein Serine-Threonine Kinases -- antagonists & inhibitors
- Proto-Oncogene Proteins -- antagonists & inhibitors
- Proto-Oncogene Proteins c-akt
- Staurosporine -- analogs & derivatives
- U937 Cells
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
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