Phytosphingosine in combination with ionizing radiation enhances apoptotic cell death in radiation-resistant cancer cells through ROS-dependent and -independent AIF release. [electronic resource]
Producer: 20050303Description: 1724-33 p. digitalISSN:- 0006-4971
- Active Transport, Cell Nucleus -- drug effects
- Apoptosis -- drug effects
- Apoptosis Inducing Factor
- Cell Nucleus -- drug effects
- Clone Cells
- Combined Modality Therapy
- Enzyme Activation -- drug effects
- Flavoproteins -- metabolism
- Gamma Rays
- Humans
- Intracellular Membranes -- drug effects
- Jurkat Cells
- Membrane Potentials -- drug effects
- Membrane Proteins -- metabolism
- Mitochondria -- drug effects
- Poly(ADP-ribose) Polymerases -- metabolism
- Proto-Oncogene Proteins c-bcl-2 -- metabolism
- Radiation Tolerance
- Reactive Oxygen Species -- pharmacology
- Sphingosine -- analogs & derivatives
- bcl-2-Associated X Protein
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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