An antisense oligonucleotide to the N-methyl-D-aspartate (NMDA) subunit NMDAR1 attenuates NMDA-induced nociception, hyperalgesia, and morphine tolerance. [electronic resource]
Producer: 20050318Description: 834-40 p. digitalISSN:- 0022-3565
- Analgesics, Opioid -- pharmacology
- Animals
- Autoradiography
- Behavior, Animal -- drug effects
- Dose-Response Relationship, Drug
- Drug Tolerance
- Excitatory Amino Acid Agonists -- pharmacology
- Excitatory Amino Acid Antagonists -- pharmacology
- Formaldehyde
- Glycine -- metabolism
- Hyperalgesia -- chemically induced
- Indoles -- pharmacology
- Injections, Spinal
- Morphine -- pharmacology
- N-Methylaspartate -- antagonists & inhibitors
- Narcotics -- pharmacology
- Oligonucleotides, Antisense -- pharmacology
- Pain -- chemically induced
- Pain Measurement -- drug effects
- RNA Probes
- RNA, Messenger -- biosynthesis
- Rats
- Reaction Time
- Receptors, N-Methyl-D-Aspartate -- biosynthesis
- Spinal Cord -- drug effects
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Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.
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