Conserved residues within the putative active site of gamma-secretase differentially influence enzyme activity and inhibitor binding. [electronic resource]
Producer: 20041027Description: 1312-20 p. digitalISSN:- 0022-3042
- Amyloid Precursor Protein Secretases
- Amyloid beta-Peptides
- Amyloid beta-Protein Precursor -- metabolism
- Aspartic Acid -- chemistry
- Aspartic Acid Endopeptidases -- pharmacology
- Binding Sites -- drug effects
- Blotting, Western -- methods
- Cell Line
- Cell Membrane -- drug effects
- Cell-Free System
- Cholic Acids -- pharmacology
- Chromosomal Proteins, Non-Histone -- chemistry
- Conserved Sequence -- physiology
- Culture Media, Conditioned -- analysis
- Detergents -- pharmacology
- Embryo, Mammalian
- Endopeptidases -- chemistry
- Enzyme Activation -- drug effects
- Enzyme Inhibitors -- pharmacology
- Humans
- Kidney
- Mutagenesis, Site-Directed -- physiology
- Peptide Fragments
- Protein Binding -- physiology
- Protein Folding
- Protein Structure, Tertiary
- Substrate Specificity
- Transfection
- Tyrosine -- chemistry
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Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
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