Identification of critical amino acid residues of human CYP2A13 for the metabolic activation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, a tobacco-specific carcinogen. [electronic resource]
Producer: 20050408Description: 1516-21 p. digitalISSN:- 0090-9556
- Amino Acid Substitution
- Amino Acids -- metabolism
- Animals
- Aryl Hydrocarbon Hydroxylases -- chemistry
- Biotransformation
- Carcinogens -- metabolism
- Computer Simulation
- Cytochrome P-450 CYP2A6
- Cytochrome P-450 Enzyme System -- metabolism
- Humans
- In Vitro Techniques
- Kinetics
- Mixed Function Oxygenases -- metabolism
- Mutagenesis, Site-Directed
- Nitrosamines -- metabolism
- Rats
- Structure-Activity Relationship
- Nicotiana -- metabolism
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Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.
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