A mutant of Sindbis virus which is able to replicate in cells with reduced CTP makes a replicase/transcriptase with a decreased Km for CTP. [electronic resource]
Producer: 20040928Description: 9645-51 p. digitalISSN:- 0022-538X
- Aedes
- Amides
- Animals
- Cell Line
- Cytidine -- analogs & derivatives
- Cytidine Triphosphate -- metabolism
- Drug Resistance, Viral -- genetics
- Genes, Viral
- Kinetics
- Mutation
- Pyrazoles
- RNA-Dependent RNA Polymerase -- genetics
- RNA-Directed DNA Polymerase -- genetics
- Ribonucleosides -- pharmacology
- Ribose
- Sindbis Virus -- drug effects
- Virus Replication -- genetics
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Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.
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