Antiplatelet activity of J78 (2-Chloro-3-[2'-bromo, 4'-fluoro-phenyl]-amino-8-hydroxy-1,4-naphthoquinone), an antithrombotic agent, is mediated by thromboxane (TX) A2 receptor blockade with TXA2 synthase inhibition and suppression of cytosolic Ca2+ mobilization. [electronic resource]
Producer: 20050413Description: 214-9 p. digitalISSN:- 0022-3565
- 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid -- metabolism
- Animals
- Arachidonic Acid -- metabolism
- Blood Platelets -- drug effects
- Calcium -- metabolism
- Collagen -- pharmacology
- Male
- Naphthoquinones -- pharmacology
- Platelet Aggregation -- drug effects
- Prostaglandins D
- Rabbits
- Thromboxane A2 -- metabolism
- Thromboxane B2 -- metabolism
- Thromboxane-A Synthase -- metabolism
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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