2-hydroxymethyl-4-[5-(4-methoxyphenyl)-3-trifluoromethyl-1H-1-pyrazolyl]-1-benzenesulfonamide (DRF-4367): an orally active COX-2 inhibitor identified through pharmacophoric modulation. [electronic resource]
Producer: 20050628Description: 2442-50 p. digitalISSN:- 1477-0520
- Animals
- Celecoxib
- Cyclooxygenase 1
- Cyclooxygenase 2
- Cyclooxygenase 2 Inhibitors
- Cyclooxygenase Inhibitors -- chemical synthesis
- Drug Design
- Drug Evaluation, Preclinical
- Humans
- Membrane Proteins
- Models, Molecular
- Molecular Structure
- Prostaglandin-Endoperoxide Synthases -- drug effects
- Pyrazoles -- administration & dosage
- Rats
- Rats, Wistar
- Structure-Activity Relationship
- Sulfonamides -- administration & dosage
- Time Factors
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Publication Type: Journal Article
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