Nitroaspirins and morpholinosydnonimine but not aspirin inhibit the formation of superoxide and the expression of gp91phox induced by endotoxin and cytokines in pig pulmonary artery vascular smooth muscle cells and endothelial cells. [electronic resource]
Producer: 20050325Description: 1140-7 p. digitalISSN:- 1524-4539
- Acetophenones -- pharmacology
- Animals
- Anti-Inflammatory Agents, Non-Steroidal -- pharmacology
- Aspirin -- analogs & derivatives
- Drug Evaluation, Preclinical
- Endothelial Cells -- drug effects
- Endothelium, Vascular -- cytology
- Enzyme Induction -- drug effects
- Epoprostenol -- biosynthesis
- Glycoproteins -- biosynthesis
- Guanylate Cyclase -- antagonists & inhibitors
- Interleukin-1 -- pharmacology
- Lipopolysaccharides -- toxicity
- Male
- Molsidomine -- analogs & derivatives
- Muscle, Smooth, Vascular -- cytology
- Myocytes, Smooth Muscle -- cytology
- NADPH Oxidases -- biosynthesis
- Nitric Oxide -- metabolism
- Nitric Oxide Donors -- pharmacology
- Nitro Compounds -- pharmacology
- Onium Compounds -- pharmacology
- Pulmonary Artery -- cytology
- Respiratory Distress Syndrome -- metabolism
- Superoxides -- metabolism
- Sus scrofa
- Tumor Necrosis Factor-alpha -- pharmacology
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Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
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