p38 MAPK mediates gamma-irradiation-induced endothelial cell apoptosis, and vascular endothelial growth factor protects endothelial cells through the phosphoinositide 3-kinase-Akt-Bcl-2 pathway. [electronic resource]
Producer: 20041124Description: 43352-60 p. digitalISSN:- 0021-9258
- Antineoplastic Agents -- pharmacology
- Apoptosis
- Cells, Cultured
- Chromones -- pharmacology
- DNA -- chemistry
- Endothelial Cells -- cytology
- Enzyme Inhibitors -- pharmacology
- Flow Cytometry
- Gamma Rays
- Genes, Dominant
- Genetic Vectors
- Humans
- Immunoblotting
- In Situ Nick-End Labeling
- Microcirculation
- Mitogen-Activated Protein Kinase 1 -- metabolism
- Mitogen-Activated Protein Kinase 3 -- metabolism
- Models, Biological
- Morpholines -- pharmacology
- Phosphatidylinositol 3-Kinases -- metabolism
- Phosphorylation
- Plasmids -- metabolism
- Protein Serine-Threonine Kinases -- metabolism
- Proto-Oncogene Proteins -- metabolism
- Proto-Oncogene Proteins c-akt
- Proto-Oncogene Proteins c-bcl-2 -- metabolism
- Recombinant Proteins -- chemistry
- Retroviridae -- genetics
- Signal Transduction
- Skin -- cytology
- Time Factors
- Transfection
- Up-Regulation
- Vascular Endothelial Growth Factor A -- metabolism
- p38 Mitogen-Activated Protein Kinases -- metabolism
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Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.
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