Antitumor agent parthenolide reverses resistance of breast cancer cells to tumor necrosis factor-related apoptosis-inducing ligand through sustained activation of c-Jun N-terminal kinase. [electronic resource]
Producer: 20041102Description: 7330-44 p. digitalISSN:- 0950-9232
- Animals
- Anti-Inflammatory Agents, Non-Steroidal -- pharmacology
- Antineoplastic Agents -- pharmacology
- Apoptosis Regulatory Proteins
- Breast Neoplasms
- Cell Division -- drug effects
- Cell Line, Tumor
- Drug Resistance, Neoplasm -- physiology
- Female
- Fibroblasts -- cytology
- Humans
- JNK Mitogen-Activated Protein Kinases
- Membrane Glycoproteins -- drug effects
- Mice
- Mice, Knockout
- Mitogen-Activated Protein Kinases -- drug effects
- NF-kappa B -- deficiency
- Oxidative Stress -- drug effects
- Sesquiterpenes -- pharmacology
- TNF-Related Apoptosis-Inducing Ligand
- Tumor Necrosis Factor-alpha -- drug effects
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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