A disubstituted succinamide is a potent sodium channel blocker with efficacy in a rat pain model. [electronic resource]
Producer: 20040924Description: 9866-76 p. digitalISSN:- 0006-2960
- Amides -- chemical synthesis
- Analgesics -- chemical synthesis
- Animals
- Binding Sites
- Biphenyl Compounds -- chemical synthesis
- Brain -- metabolism
- Cell Line
- Disease Models, Animal
- Formaldehyde -- administration & dosage
- Ganglia, Spinal -- drug effects
- Humans
- Mice
- Muscle Proteins -- biosynthesis
- NAV1.2 Voltage-Gated Sodium Channel
- NAV1.5 Voltage-Gated Sodium Channel
- NAV1.7 Voltage-Gated Sodium Channel
- Nerve Tissue Proteins -- antagonists & inhibitors
- Pain Measurement -- drug effects
- Patch-Clamp Techniques
- Rats
- Recombinant Proteins -- antagonists & inhibitors
- Sodium Channel Blockers -- chemical synthesis
- Sodium Channels -- biosynthesis
- Succinates
- Synaptosomes -- metabolism
- Tetrodotoxin -- antagonists & inhibitors
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Publication Type: Journal Article
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