The c-Raf inhibitor GW5074 provides neuroprotection in vitro and in an animal model of neurodegeneration through a MEK-ERK and Akt-independent mechanism. [electronic resource]
Producer: 20040910Description: 595-608 p. digitalISSN:- 0022-3042
- Animals
- Cell Death -- drug effects
- Cells, Cultured
- Disease Models, Animal
- Enzyme Inhibitors -- pharmacology
- Farnesol -- analogs & derivatives
- Huntington Disease -- chemically induced
- Indoles -- pharmacology
- Mitogen-Activated Protein Kinase Kinases -- antagonists & inhibitors
- Mitogen-Activated Protein Kinases -- antagonists & inhibitors
- Neurodegenerative Diseases -- chemically induced
- Neurons -- cytology
- Neuroprotective Agents -- pharmacology
- Neurotoxins
- Nitro Compounds
- Phenols -- pharmacology
- Propionates
- Protein Serine-Threonine Kinases -- antagonists & inhibitors
- Proto-Oncogene Proteins -- antagonists & inhibitors
- Proto-Oncogene Proteins c-akt
- Proto-Oncogene Proteins c-raf -- antagonists & inhibitors
- Rats
- Rats, Sprague-Dawley
- Salicylates -- pharmacology
- Signal Transduction -- drug effects
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Publication Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
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