Comparative effects of GLP-1 and GIP on cAMP production, insulin secretion, and in vivo antidiabetic actions following substitution of Ala8/Ala2 with 2-aminobutyric acid. [electronic resource]
Producer: 20040816Description: 136-43 p. digitalISSN:- 0003-9861
- Adenylyl Cyclases -- metabolism
- Alanine -- chemistry
- Aminobutyrates -- pharmacology
- Animals
- Cells, Cultured
- Chromatography, High Pressure Liquid
- Cyclic AMP -- metabolism
- Diabetes Mellitus -- drug therapy
- Dipeptidyl Peptidase 4 -- chemistry
- Dose-Response Relationship, Drug
- Gastric Inhibitory Polypeptide -- chemistry
- Glucagon -- chemistry
- Glucagon-Like Peptide 1
- Glucose -- metabolism
- Humans
- Insulin -- metabolism
- Insulin Secretion
- Islets of Langerhans -- metabolism
- Mice
- Mice, Obese
- Models, Chemical
- Peptide Fragments -- chemistry
- Peptides -- chemistry
- Protein Precursors -- chemistry
- Protein Structure, Tertiary
- Spectrometry, Mass, Electrospray Ionization
- Time Factors
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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