Glucose- and interleukin-1beta-induced beta-cell apoptosis requires Ca2+ influx and extracellular signal-regulated kinase (ERK) 1/2 activation and is prevented by a sulfonylurea receptor 1/inwardly rectifying K+ channel 6.2 (SUR/Kir6.2) selective potassium channel opener in human islets. [electronic resource]
Producer: 20040916Description: 1706-13 p. digitalISSN:- 0012-1797
- ATP-Binding Cassette Transporters
- Aged
- Apoptosis -- drug effects
- Bridged Bicyclo Compounds, Heterocyclic -- pharmacology
- Calcium -- metabolism
- Calcium Channels, L-Type -- metabolism
- Cells, Cultured
- Cyclic S-Oxides -- pharmacology
- Diazoxide -- pharmacology
- Drug Synergism
- Enzyme Activation -- physiology
- Glucose -- pharmacology
- Humans
- Interleukin-1 -- pharmacology
- Islets of Langerhans -- drug effects
- Middle Aged
- Mitogen-Activated Protein Kinases -- metabolism
- Potassium Channels -- drug effects
- Potassium Channels, Inwardly Rectifying -- drug effects
- Receptors, Drug
- Sulfonylurea Receptors
- Tolbutamide -- pharmacology
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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