Targeted disruption of TGF-beta/Smad3 signaling modulates skin fibrosis in a mouse model of scleroderma. [electronic resource]
Producer: 20040903Description: 203-17 p. digitalISSN:- 0002-9440
- Actins -- biosynthesis
- Animals
- Bleomycin -- pharmacology
- Blotting, Western
- Cells, Cultured
- Collagen -- biosynthesis
- Connective Tissue Growth Factor
- Disease Models, Animal
- Fibroblasts -- drug effects
- Fibronectins -- biosynthesis
- Fibrosis -- chemically induced
- Flow Cytometry
- Gene Expression Regulation -- drug effects
- Gene Targeting
- Hydroxyproline -- analysis
- Immediate-Early Proteins -- drug effects
- Immunohistochemistry
- In Situ Hybridization
- Intercellular Signaling Peptides and Proteins -- metabolism
- Mice
- Mice, Knockout
- Scleroderma, Systemic -- metabolism
- Signal Transduction -- drug effects
- Skin -- chemistry
- Trans-Activators -- genetics
- Transforming Growth Factor beta -- genetics
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Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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