Neuroprotective effects of the mGlu5R antagonist MPEP towards quinolinic acid-induced striatal toxicity: involvement of pre- and post-synaptic mechanisms and lack of direct NMDA blocking activity. [electronic resource]
Producer: 20040722Description: 1479-89 p. digitalISSN:- 0022-3042
- Animals
- Body Weight -- drug effects
- Calcium -- metabolism
- Cells, Cultured
- Electroencephalography -- drug effects
- Excitatory Amino Acid Antagonists -- pharmacology
- Glutamic Acid -- metabolism
- L-Lactate Dehydrogenase -- metabolism
- Male
- Maze Learning -- drug effects
- Microdialysis
- N-Methylaspartate -- pharmacology
- Neostriatum -- drug effects
- Neurons -- drug effects
- Neuroprotective Agents -- pharmacology
- Neurotoxicity Syndromes -- pathology
- Neurotoxins -- antagonists & inhibitors
- Pyridines -- pharmacology
- Quinolinic Acid -- antagonists & inhibitors
- Rats
- Rats, Wistar
- Receptor, Metabotropic Glutamate 5
- Receptors, Metabotropic Glutamate -- antagonists & inhibitors
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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