Nitro and amino substitution within the A-ring of 5H-8,9-dimethoxy-5-(2-N,N-dimethylaminoethyl)dibenzo[c,h][1,6]naphthyridin-6-ones: influence on topoisomerase I-targeting activity and cytotoxicity. [electronic resource]
Producer: 20050111Description: 3731-42 p. digitalISSN:- 0968-0896
- Amination
- Antineoplastic Agents -- chemical synthesis
- Cell Line, Tumor
- DNA -- metabolism
- DNA Topoisomerases, Type I -- metabolism
- Enzyme Inhibitors -- chemical synthesis
- Humans
- Inhibitory Concentration 50
- Molecular Conformation
- Molecular Structure
- Naphthyridines -- chemical synthesis
- Nitrogen -- chemistry
- Static Electricity
- Topoisomerase I Inhibitors
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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