A human and mouse pregnane X receptor reporter gene assay in combination with cytotoxicity measurements as a tool to evaluate species-specific CYP3A induction. [electronic resource]
Producer: 20040629Description: 23-33 p. digitalISSN:- 0300-483X
- Androstadienes -- toxicity
- Animals
- Antineoplastic Agents -- toxicity
- Biological Assay
- Cell Line, Tumor
- Cell Survival -- drug effects
- Cytochrome P-450 CYP3A
- Cytochrome P-450 Enzyme System -- biosynthesis
- Dose-Response Relationship, Drug
- Enzyme Induction
- Formazans -- metabolism
- Genes, Reporter
- Hepatocytes -- drug effects
- Humans
- L-Lactate Dehydrogenase -- metabolism
- Mice
- Pregnane X Receptor
- Receptors, Cytoplasmic and Nuclear -- genetics
- Receptors, Steroid -- genetics
- Species Specificity
- Tetrazolium Salts -- metabolism
- Xenobiotics -- toxicity
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Publication Type: Comparative Study; Journal Article
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