Transgenic mice overexpressing the full-length neurotrophin receptor trkB exhibit increased activation of the trkB-PLCgamma pathway, reduced anxiety, and facilitated learning. [electronic resource]
Producer: 20040720Description: 166-81 p. digitalISSN:- 1044-7431
- Animals
- Anxiety -- genetics
- Avoidance Learning -- physiology
- Brain Chemistry -- genetics
- Brain-Derived Neurotrophic Factor -- metabolism
- Cerebral Cortex -- cytology
- Exploratory Behavior -- physiology
- Female
- Hippocampus -- cytology
- Learning -- physiology
- Long-Term Potentiation -- genetics
- Male
- Maze Learning -- physiology
- Mice
- Mice, Transgenic
- Phospholipase C gamma
- Phosphorylation
- RNA, Messenger -- metabolism
- Receptor, trkB -- biosynthesis
- Signal Transduction -- genetics
- Synaptic Transmission -- genetics
- Type C Phospholipases -- metabolism
- Up-Regulation -- genetics
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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