Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. [electronic resource]
Producer: 20040525Description: 2129-39 p. digitalISSN:- 1533-4406
- Adenocarcinoma -- drug therapy
- Adult
- Aged
- Aged, 80 and over
- Amino Acid Sequence
- Antineoplastic Agents -- therapeutic use
- Base Sequence
- Carcinoma, Non-Small-Cell Lung -- drug therapy
- DNA Mutational Analysis
- Drug Resistance, Neoplasm -- genetics
- Epidermal Growth Factor -- metabolism
- ErbB Receptors -- chemistry
- Female
- Gefitinib
- Genes, erbB-1
- Heterozygote
- Humans
- Lung Neoplasms -- drug therapy
- Male
- Middle Aged
- Molecular Sequence Data
- Mutation
- Protein-Tyrosine Kinases -- antagonists & inhibitors
- Quinazolines -- therapeutic use
- Sequence Deletion
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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