Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7. [electronic resource]
Producer: 20050714Description: 2116-25 p. digitalISSN:- 0261-4189
- Animals
- Cell Cycle Proteins -- genetics
- Cells, Cultured
- Cyclin E -- genetics
- F-Box Proteins -- genetics
- F-Box-WD Repeat-Containing Protein 7
- Humans
- Ligases -- genetics
- Mice
- Mice, Knockout
- Peptides -- genetics
- Phosphorylation
- Proto-Oncogene Proteins c-myc -- metabolism
- RNA Interference
- Recombinant Proteins -- genetics
- S-Phase Kinase-Associated Proteins -- metabolism
- Serine -- metabolism
- Stem Cells -- cytology
- Threonine -- metabolism
- Transcriptional Activation
- Ubiquitin -- metabolism
- Ubiquitin-Protein Ligases -- genetics
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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