Drug-mediated sensitization to TRAIL-induced apoptosis in caspase-8-complemented neuroblastoma cells proceeds via activation of intrinsic and extrinsic pathways and caspase-dependent cleavage of XIAP, Bcl-xL and RIP. [electronic resource]
Producer: 20040823Description: 5415-25 p. digitalISSN:- 0950-9232
- Antineoplastic Agents -- pharmacology
- Apoptosis -- drug effects
- Apoptosis Regulatory Proteins
- Caspase 8
- Caspases -- metabolism
- Cycloheximide -- pharmacology
- Humans
- Membrane Glycoproteins -- pharmacology
- Mitochondria -- drug effects
- Neuroblastoma -- drug therapy
- Protein Synthesis Inhibitors -- pharmacology
- Proteins -- metabolism
- Proto-Oncogene Proteins c-bcl-2 -- metabolism
- Receptor-Interacting Protein Serine-Threonine Kinases
- Receptors, TNF-Related Apoptosis-Inducing Ligand
- Receptors, Tumor Necrosis Factor -- biosynthesis
- TNF-Related Apoptosis-Inducing Ligand
- Tumor Cells, Cultured
- Tumor Necrosis Factor-alpha -- pharmacology
- X-Linked Inhibitor of Apoptosis Protein
- bcl-X Protein
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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