Preferential inhibition of T helper 1, but not T helper 2, cytokines in vitro by L-826,141 [4-[2-(3,4-Bisdifluromethoxyphenyl)-2-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-phenyl]-ethyl]3-methylpyridine-1-oxide], a potent and selective phosphodiesterase 4 inhibitor. [electronic resource]
Producer: 20050328Description: 752-60 p. digitalISSN:- 0022-3565
- 3',5'-Cyclic-AMP Phosphodiesterases -- antagonists & inhibitors
- Animals
- Cyclic Nucleotide Phosphodiesterases, Type 4
- Cytokines -- antagonists & inhibitors
- Dose-Response Relationship, Drug
- Humans
- Immunosuppressive Agents -- pharmacology
- Mice
- Mice, Inbred BALB C
- Mice, Transgenic
- Phosphodiesterase Inhibitors -- chemistry
- Pyridines -- chemistry
- Th1 Cells -- drug effects
- Th2 Cells -- drug effects
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Publication Type: Comparative Study; Journal Article
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