Functional domains in presenilin 1: the Tyr-288 residue controls gamma-secretase activity and endoproteolysis. [electronic resource]
Producer: 20040708Description: 23925-32 p. digitalISSN:- 0021-9258
- Alanine -- chemistry
- Amino Acid Sequence
- Amyloid Precursor Protein Secretases
- Animals
- Aspartic Acid Endopeptidases
- Cells, Cultured
- Embryo, Mammalian -- cytology
- Endopeptidases -- metabolism
- Enzyme-Linked Immunosorbent Assay
- Genes, Reporter
- Immunoblotting
- Luciferases -- metabolism
- Membrane Proteins -- chemistry
- Mice
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Mutation
- Precipitin Tests
- Presenilin-1
- Protein Structure, Tertiary
- Stem Cells -- cytology
- Subcellular Fractions
- Transfection
- Tyrosine -- chemistry
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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