Co-expressed presenilin 1 NTF and CTF form functional gamma-secretase complexes in cells devoid of full-length protein. [electronic resource]
Producer: 20040426Description: 44-53 p. digitalISSN:- 0022-3042
- Amyloid Precursor Protein Secretases
- Amyloid beta-Peptides -- metabolism
- Animals
- Aspartic Acid Endopeptidases
- Blastocyst -- cytology
- Catalytic Domain -- genetics
- Cell Line
- Endopeptidases -- metabolism
- Enzyme Activation -- genetics
- Genes, Reporter
- Macromolecular Substances
- Membrane Glycoproteins -- metabolism
- Membrane Proteins -- genetics
- Mice
- Peptide Fragments -- genetics
- Presenilin-1
- Recombinant Fusion Proteins -- genetics
- Sequence Deletion
- Stem Cells -- cytology
- Structure-Activity Relationship
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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